AN L - Kynurenine / Aryl Hydrocarbon Receptor Pathway Mediates Brain Damage After Experimental Stroke Running title :
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چکیده
Running title: Cuartero et al.; L-Kyn/AhR mediate damage after stroke Address for r r Co Co Corr rr rres es spo po p nd nd n en en enc c ce: Abstract Background—AhR (Aryl hydrocarbon receptor) is a transcription factor that belongs to the basic
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L-kynurenine/aryl hydrocarbon receptor pathway mediates brain damage after experimental stroke.
BACKGROUND Aryl hydrocarbon receptor (AhR) is a transcription factor that belongs to the basic helix-loop-helix PAS (Per-Arnt-Sim homology domain) family known to mediate the toxic and carcinogenic effects of xenobiotics. Interestingly, AhR is widely expressed in the central nervous system, but its physiological and pathological roles are still unclear. METHODS AND RESULTS To define the role ...
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